Search results for "reversible polyploidy"

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Activation of self-renewal and meiotic genes in tumour cell lines resistant to genotoxic treatment

2014

Pašatjaunošanās un meijotisko gēnu aktivācija pēc genotoksiskas apstrādes rezistentās audzēju šūnu līnijās Šajā darbā tika pētīta iespējamā saistība starp poliploīdijas un dzimumšūnu līnijai raksturīgo gēnu indukciju pēc pretvēža apstrādes atkarībā no TP53 statusa un audzēju šūnu rezistence pret DNS bojājumu. Pirmo reizi tika atrasta un citoloģiski raksturota galveno cilmestības transkripcijas faktoru OCT4, NANOG un SOX2 ekspresijas aktivācija, kas izraisīta pārkāpjot tetraploīdo barjeru pēc DNS bojājuma TP53 mutantās, bet ne funkcionālās audzēja šūnas, kā arī galvenā mejotiskā kohezīna REC8 ekspresija somatisko audzēja šūnu līnijās, kas apstrādātas ar jonizējošo starojumu vai topoizomeraze…

Molecular Biology and Biochemistryreversible polyploidyatgriezeniska poliploīdijaembrionālo cilmes šūnu gēnilymphoma cell lineslimfomu šūnu līnijasDNA damageDzīvās dabas zinātnesBioloģijaDNS bojājumsembryonal stem cell genes

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PEPhysical Sciences and Engineering
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- PE1Mathematics
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LSLife Sciences
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SHSocial Sciences and Humanities
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